Table 2.
Mixed model results comparing cognitive domains in LOD, EOD, and NDC. Model coefficients and standard errors (in parentheses) are shown along with an F-test.
| Attention/Processing Speedb | Verbal Abilityb | Delayed Memorya | Visuospatial Abilityb | Executive Functionsc | Global Functionb | |
|---|---|---|---|---|---|---|
| Intercept | 1.813 (0.416) | 0.540 (0.265) | 1.409 (0.363) | 1.346 (0.376) | 2.088 (0.491) | 0.974 (0.239) |
| Baseline Neuropsych |
0.854 (0.037) F (1314) = 519.4 |
0.925 (0.031) F (1315) = 910.4 |
0.792 (0.035) F (1142) = 499.4 |
0.578 (0.044) F (1314) = 171.1 |
0.420 (0.046) F (1579) = 83.95 |
0.838 (0.036) F (1338) = 545.3 |
| Age |
−0.025 (0.005) F (1314) = 21.68 |
−0.004 (0.003) F (1315) = 1.53 |
−0.020 (0.005) F (1142) = 17.95 |
−0.020 (0.005) F (1314) = 17.34 |
−0.035 (0.006) F (1579) = 31.19 |
−0.013 (0.003) F (338) = 16.72 |
| Cumulative Illness Rating Scale (CIRS-G) |
−0.001 (0.009) F (1314) = 0.01 |
−0.009 (0.006) F (1315) = 2.44 |
0.000 (0.008) F (1142) = 0.00 |
−0.016 (0.008) F (1314) = 3.84 |
0.004 (0.010) F (1579) = 0.17 |
−0.005 (0.005) F (1338) = 0.89 |
| Education |
0.007 (0.012) F (1,314)=0.32 |
−0.007 (0.009) F (1,315)=0.67 |
0.001 (0.011) F (1,142)=0.00 |
0.025 (0.011) F (1,314)=5.01 |
0.047 (0.015) F (1,579)=10.39 |
0.010 (0.008) F (1,338)=1.75 |
| Sex (Female) |
0.124 (0.069) F (1,314)=3.19 |
−0.064 (0.046) F (1,315)=1.91 |
−0.006 (0.063) F (1,142)=0.01 |
−0.088 (0.065) F (1,314)=1.81 |
−0.032 (0.085) F (1,579)=0.14 |
−0.017 (0.042) F (1,338)=0.16 |
| Depression severity (HDRS total) |
−0.016 (0.007) F (1314) = 5.48 |
−0.004 (0.004) F (1315) = 1.22 |
−0.005 (0.006) F (1142) = 0.79 |
0.001 (0.006) F (1314) = 0.05 |
−0.008 (0.007) F (1579) = 1.13 |
−0.008 (0.004) F (1338) = 4.67 |
| Group* | F (2314) = 2.10 | F (2315) = 0.09 | F (2142) = 0.41 | F (2314) = 0.65 | F (2579) = 1.42 | F (2338) = 0.39 |
| Early | −0.212 (0.118) | 0.027 (0.075) | −0.088 (0.097) | −0.113 (0.102) | −0.069 (0.140) | −0.057 (0.067) |
| Late | 0.003 (0.120) | 0.028 (0.074) | −0.039 (0.096) | −0.078 (0.102) | −0.231 (0.140) | −0.039 (0.067) |
| Linear Time |
−0.076 (0.038) F (1241) = 21.67 |
0.006 (0.017) F (1242) = 7.64 |
0.198 (0.057) F (1239) = 8.70 |
−0.099 (0.026) F (1243) = 33.26 |
−0.041 (0.027) F (1579) = 11.17 |
−0.038 (0.018) F (1246) = 26.99 |
| Quadratic Time | – | – |
−0.027 (0.010) F (1173) = 7.90, p ≤ 0.01 |
– | – | – |
| Linear Time x Group* | F (2314) = 1.97 | F (2315) = 3.23 | F (2142) = 3.44 | F (2314) = 1.12 | F (2579) = 0.38 | F (2338) = 1.48 |
| Early | 0.002 (0.055) | −0.041 (0.025) | −0.018 (0.035) | 0.040 (0.037) | −0.033 (0.039) | −0.010 (0.026) |
| Late | −0.102 (0.058) | −0.064 (0.026) | −0.094 (0.037) | −0.018 (0.040) | −0.009 (0.041) | −0.045 (0.027) |
Significant values are bolded (p < 0.05).
*Reference = Controls.
aRandom intercept, slope and quadratic.
bRandom intercept and slope.
cRandom intercept.