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. 2021 Mar 2;12:1386. doi: 10.1038/s41467-021-21639-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a NAb titres in animals from 1st to 4th week of immunisation. b NAb titres in animals at 0, 1, 3, 5 and 7 DPI. c NAb titres in animal samples of 7 DPI with homologous strain 770 and heterologous strain Q-100 and Q-111 of SARS-CoV-2. The statistical significance was assessed using the Kruskal–Wallis test followed by the two-tailed Mann–Whitney test between two groups; P values of < 0.05 were considered to be statistically significant. Data are presented as mean values +/− standard deviation (SD). Statistical comparison was done by comparing the vaccinated group with the placebo group as a control. Group I = blue, group II = pink, group III = green and group IV = purple, number of animals = 5 animals in each group. Source data are provided as a Source Data file.