Table 3.

Results of common variants analysis: the 20 most strongly associated genes in 100 non-Hispanic Caucasian preterm infants by SKAT-O.

Rank	Official Symbol	Gene name	Entrez gene ID	P value	Number of included variants	Number of variant alleles
						No or mild ROP	Severe ROP
1	ZNF341	Zinc finger protein 341	84905	8.28E−05	6	29	43
2	ALG10B	ALG10B, alpha-1,2-glucosyltransferase	144245	2.82E−04	4	47	63
3	OR4D6	Olfactory receptor family 4 subfamily D member 6	219983	3.93E−04	5	77	90
4	KCNE1	Potassium voltage-gated channel subfamily E regulatory subunit 1	3753	4.14E−04	1	16	47
5	FAM198A	Family with sequence similarity 198 member A	729085	4.97E−04	7	145	216
6	PI16	Peptidase inhibitor 16	221476	5.23E−04	2	50	56
7	CSTF2T	Cleavage stimulation factor subunit 2 tau variant	23283	5.89E−04	3	11	32
8	SPANXD	SPANX family member D	64648	7.71E−04	2	38	34
9	RNASE11	Ribonuclease A family member 11	122651	7.88E−04	3	27	70
10	COG7	Component of oligomeric golgi complex 7	91949	7.99E−04	3	0	15
11	NEDD9	Neural precursor cell expressed, developmentally down-regulated 9	4739	8.37E−04	5	89	146
12	OBSCN	Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	84033	8.59E−04	80	495	634
13	PKP3	Plakophilin 3	11187	9.70E−04	11	177	223
14	MTPN	Myotrophin	136319	1.06E−03	1	2	12
15	TLDC1	TBC/LysM-associated domain containing 1	57707	1.09E − 03	8	87	118
16	TNK2	Tyrosine kinase non receptor 2	10188	1.13E−03	13	88	85
17	CAPN2	Calpain 2	824	1.25E−03	5	31	49
18	FAT1	FAT atypical cadherin 1	2195	1.29E−03	44	256	305
19	KEL	Kell blood group, metallo-endopeptidase	3792	1.33E−03	6	12	4
20	ZUFSP	Zinc finger with UFM1 specific peptidase domain	221302	1.48E−03	4	23	42