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. 2021 Mar 2;11:4977. doi: 10.1038/s41598-021-83696-x

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© The Author(s) 2021

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The Amino acid substitution heatmap. The one-letter codes of amino acids at the left and bottom side of the map correspond to the reference and mutant amino acids, respectively. A color index (white to red) was assigned for amino acid substitutions according to the number of their occurrences ranged from 0 to 12. The gray blocks show the amino acid replacements that are not allowed to occur by single nucleotide substitution.