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. 2021 Mar 2;11:4976. doi: 10.1038/s41598-021-83771-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Absent migration of xenotransplanted MAPRE2 deficient neural crest progenitors in chicken embryos. Representative whole mount bright field and fluorescent images of chicken embryos at development stage HH 20 with corresponding sagittal sections. Embryos have been transplanted with EBs at day 5 of neural crest differentiation⁴⁹, generated from EmGFP tagged MAPRE2 deficient iPSCs. Sagittal sections have been stained against endogenous EmGFP. WT/WT cells are observed migrating into the branchial arches and facial mesenchyme on whole mount and in sections, indicated by white arrows. Q152*^KI/WT cells emerge from the EB but fail to migrate away towards the branchial arches and facial mesenchyme (indicated by white arrows). Complete MAPRE2 knock out cells (Q152*^KI/Q152*^KI) fail to emerge from the EB and migrate. (Ant. anterior, Vent. ventral, Dor. dorsal, Post. posterior).