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Schematic overview of Aβ-independent roles for apoE in Alzheimer’s disease pathology. The isoform-dependent effects of APOE are indicated. Abbreviations: apoE, apolipoprotein E; NFT, neurofibrillary tangle; BBB, blood brain barrier; IL, interleukin; TNF-α, Tumor necrosis factor-α; ROS, reactive oxygen species.
