TABLE 1.

APOE genotypes, allele frequency distribution, and odds ratio for developing AD, stratified by AD patient cases and controls on five ethnic groups (Farrer et al., 1997).

		APOE genotype {(frequency (%) /						APOE allele
		AD Odds ratio (95 % confidence interval)}						frequency (%)
Ethnic groups	No	E2/E2	E2/E3	E2/E4	E3/E3	E3/E4	E4/E4	E2	E3	E4
CAUCASIAN CASE PATIENTS	5107	0.2/0.9	4.8/0.6	2.6/1.2	36.4/1.0	41.1/2.7	14.8/12.5	3.9	59.4	36.7
Controls	6262	0.8	12.7	2.6	60.9	21.3	1.8	8.4	77.9	13.7
AFRICAN AMERICAN	235	1.7/2.4	9.8/0.6	2.1/1.8	36.2/1.0	37.9/1.1	12.3/5.7	7.7	59.1	32.2
CASE PATIENTS
Controls	240	0.8	12.9	2.1	50.4	31.8	2.1	8.3	72.7	19.0
HISPANIC	261	0.4/2.6	9.6/0.6	2.3/3.2	54.4/1.0	30.7/2.2	2.7/2.2	6.3	74.5	19.2
CASE PATIENTS
Controls	267	0.4	12.0	0.8	67.4	17.6	1.9	6.7	82.3	11.0
JAPANESE	336	0.3/1.1	3.9/0.9	0.9/2.4	49.1/1.0	36.9/5.6	8.9/33.1	2.7	69.5	27.8
CASE PATIENTS
Controls	1977	0.4	6.9	0.8	75.7	15.5	0.8	4.2	86.9	8.9