Table 3.

Accuracy of new Corvis ST parameters in identifying SKC and KC eyes.

Parameters	AUC (95%CI)	Youden index	Cut off	Sensitivity (%)	Specificity (%)
SKC versus control
Max inverse radius	0.626 (0.555, 0.693)	0.23	> 0.19	50	73
DA ratio max (2 mm)	0.684 (0.615, 0.748)	0.33	> 4.47	81	52
Pachy slope	0.538 (0.466, 0.608)	0.16	> 44.30	46	70
DA ratio max (1 mm)	0.673 (0.603, 0.737)	0.31	> 1.60	80	51
ARTh	0.618 (0.547, 0.686)	0.30	≤ 434.02	51	79
Integrated radius	0.668 (0.598, 0.733)	0.33	> 8.94	81	52
SP-A1	0.753 (0.687, 0.811)	0.40	≤ 107.30	66	74
CBI	0.703 (0.635, 0.766)	0.38	> 0.05	56	82
KC versus SKC
Max inverse radius	0.889 (0.837, 0.929)	0.65	> 0.20	87	78
DA ratio max (2 mm)	0.903 (0.853, 0.940)	0.69	> 5.29	80	89
Pachy slope	0.908 (0.859, 0.944)	0.69	> 55.49	73	96
DA ratio max (1 mm)	0.843 (0.785, 0.891)	0.61	> 1.67	79	82
ARTh	0.980 (0.949, 0.994)	0.88	≤ 319.83	89	99
Integrated radius	0.932 (0.887, 0.962)	0.72	> 10.86	81	91
SP-A1	0.893 (0.841, 0.932)	0.64	≤ 82.03	72	92
CBI	0.992 (0.967, 0.999)	0.93	> 0.87	97	96
KC versus control
Max inverse radius	0.923 (0.878, 0.956)	0.71	> 0.19	95	76
DA ratio max (2 mm)	0.953 (0.913, 0.978)	0.77	> 5.13	83	94
Pachy slope	0.919 (0.873, 0.953)	0.69	> 48.46	87	82
DA ratio max (1 mm)	0.914 (0.866, 0.949)	0.71	> 1.66	86	85
ARTh	0.992 (0.967, 0.999)	0.96	≤ 364.89	97	99
Integrated radius	0.965 (0.929, 0.986)	0.79	> 10.50	86	93
SP-A1	0.973 (0.939, 0.991)	0.84	≤ 91.64	87	97
CBI	0.999 (0.980, 1.000)	0.99	> 0.50	99	100

SKC Subclinical keratoconus, KC Keratoconus, DA Deformation amplitude, ARTh Ambrósio’s relational thickness horizontal, bIOP Biomechanical corrected intraocular pressure, SP-A1 Stiffness parameter at the first applanation, CBI Corvis biomechanical index.