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. 2021 Mar 2;6:32. doi: 10.1038/s41541-021-00291-x

Fig. 3. Vaccination of guinea pigs with ChAdOx1-Lassa-GPC induces a humoral immune response.

Fig. 3

a Serum samples were collected at 28 days post prime and post boost vaccination in the survival cohort (n = 6) of the prime-boost experimental group. LASV GP-specific IgG antibody titers in twofold serial-diluted sera were measured by ELISA. Horizontal lines indicate mean titers. Statistical significance between the post prime and post boost antibody titers was determined via Wilcoxon matched-pairs signed rank test (*p = 0.0312). b Summary of experimental timeline. VL = vaccination with ChAdOx1-Lassa-GPC (n = 10 per group); VG = vaccination with ChAdOx1-GFP (n = 10); B = blood collection; C = LASV challenge; N = planned necropsy for comparative virology (n = 4 per group); S = survival or study endpoint (after adjustment for loss of animals n = 5, n = 6, and n = 4 for the prime-boost, prime, and control experimental groups, respectively).