Table 1.
Clinical and Demographic Characteristics of Mayo PGRN-AMPS Study Participants Stratified by Remission Status.
| Characteristic | Number of Available Measurements | Mean (SD)/ Percentage (Na) | Remissiona (N = 64) | Response without Remission (N = 30) | Partial-Response (N = 30) | Treatment Failure (N = 12) | Test Statistic |
|---|---|---|---|---|---|---|---|
| Age (years) | 136 | 40.17 (13.60) | 40.76 (1.72) | 35.58 (1.91) | 41.31 (2.26) | 45.75 (5.63) | F = 1.4 d.f. = 3,132 P = 0.24 |
| Sex: Male | 136 | 36% (49) | 34% (22) | 30% (9) | 29% (13) | 50% (6) | Chi-square = 1.8 d.f. = 3 P = 0.62 |
| Body Mass Index (kg/m2) | 97 | 28.77 (6.52) | 29.19 (6.58) | 26.58 (5.43) | 29.42 (7.12) | 29.54 (6.83) | F = 1 d.f. = 3,93 P = 0.39 |
| HRSD17 at Baseline | 136 | 23.38 (4.91) | 22.76 (0.66) | 25.70 (0.85) | 22.83 (0.70) | 22.25 (1.30) | F = 214 d.f. = 3,132 P < 0.001 |
| HRSD17 at Week 8 | 136 | 8.74 (5.49) | 4.06 (0.27) | 10.10 (0.37) | 13.43 (0.47) | 18.50 (1.15) | F = 3.4 d.f. = 3,132 P = 0.018 |
Remission status based on week-8 HRSD17 score. BMI measurement is available only at baseline. a) N number.
PGRN-AMPS Mayo Pharmacogenomics Research Network Antidepressant Medication Pharmacogenomic Study, BMI body mass index, HRSD17 The 17-item Hamilton Rating Scale for Depression.