Table 1.
Descriptive statistics of participant demographic and clinical characteristics stratified by having any aFRP domains and HIV
| Not frail, n=2794 | Having any aFRP domain, n=1647 | |||||
|---|---|---|---|---|---|---|
| PLWH (%), n=1206 | Uninfected (%), n=1588 | p-value | PLWH (%), n=556 | Uninfected (%), n=1091 | p-value | |
| Sex | -- | -- | <0.05 | -- | -- | <0.05 |
| Male | 98 | 92 | -- | 97 | 90 | -- |
| Race | -- | -- | <0.05 | -- | -- | <0.05 |
| White | 24 | 21 | -- | 30 | 25 | -- |
| Black | 67 | 66 | -- | 61 | 60 | -- |
| Hispanic | 9 | 10 | -- | 9 | 11 | -- |
| Other | 1 | 3 | -- | 1 | 4 | -- |
| Age, mean (SD) | 55 (9) | 56 (9) | <0.05 | 56 (8) | 57 (9) | 0.39 |
| Number of comorbid conditions, IQR | 3 (2, 4) | 3 (2, 5) | <0.05 | 4 (2, 5) | 4 (3, 6) | <0.05 |
| Hypertension | 10 | 48 | <0.05 | 15 | 58 | <0.05 |
| Cardiovascular disease a | 6 | 10 | <0.05 | 14 | 17 | 0.08 |
| Hepatitis C | 46 | 27 | <0.05 | 55 | 31 | <0.05 |
| Diabetes Mellitus | 22 | 30 | <0.05 | 30 | 42 | <0.05 |
| Pulmonary disease | 5 | 8 | <0.05 | 11 | 13 | 0.21 |
| Liver disease b | 46 | 27 | <0.05 | 56 | 32 | <0.05 |
| Gastroesophageal reflux disease | 3 | 8 | <0.05 | 5 | 11 | <0.05 |
| Alcohol related diagnoses | 8 | 14 | <0.05 | 13 | 15 | 0.32 |
| Drug related diagnoses | 15 | 19 | <0.05 | 18 | 18 | 0.90 |
| Major Depressive Disorder | 6 | 7 | 0.69 | 13 | 13 | 0.81 |
| Post-Traumatic Stress Disorder | 7 | 12 | <0.05 | 12 | 19 | <0.05 |
| Bipolar disorder | 3 | 6 | <0.05 | 6 | 6 | 0.75 |
| Chronic pain-related diagnoses c | 29 | 46 | <0.05 | 43 | 61 | <0.05 |
| FIB-4 | -- | -- | <0.05 | -- | -- | <0.05 |
| <1.45 | 59 | 80 | -- | 55 | 80 | -- |
| 1.45 – 3.25 | 35 | 18 | -- | 36 | 18 | -- |
| >3.25 | 6 | 3 | -- | 9 | 2 | -- |
| Hemoglobin (g/dL), IQR | 13.9 (12.8, 14.9) | 14.5 (13.7, 15.3) | <0.05 | 13.9 (12.6, 15.0) | 14.5 (13.5, 15.4) | <0.05 |
| Estimated glomerular filtration rate (mL/min), IQR | 99 (85, 116) | 95 (82, 111) | <0.05 | 99 (84, 116) | 93 (80, 108) | <0.05 |
| Hospitalized | 14 | 14 | 0.78 | 25 | 20 | <0.05 |
| Died | 8 | 1 | <0.05 | 16 | 4 | <0.05 |
| Domains of adapted frailty-related phenotype | -- | -- | -- | -- | -- | -- |
| Shrinking | -- | -- | -- | 17 | 13 | 0.05 |
| Exhaustion | -- | -- | -- | 32 | 31 | 0.87 |
| Slowness | -- | -- | -- | 14 | 16 | 0.28 |
| Low physical activity | -- | -- | -- | 74 | 81 | <0.05 |
| adapted Frailty-Related Phenotype | -- | -- | -- | -- | -- | 0.45 |
| Pre-Frail | -- | -- | -- | 93 | 92 | -- |
| Frail | -- | -- | -- | 7 | 8 | -- |
| Viral load ≤50 copies/mL | 72 | -- | 74 | -- | 0.28 | |
a
Cardiovascular disease is a composite of coronary artery disease/myocardial infarction, peripheral vascular disease, stroke
b
Liver disease is a combination of end-stage liver disease, decompensated liver disease, Hepatitis B and Hepatitis C
c
Chronic pain is composed of back, neck, temporomandibular, extremity, menstrual, rheumatoid arthritis, neuropathic and other pain