Fig. 1.

Overview of the molecular mechanisms governing SRF binding to cofactors and the subsequent transcription of target genes in cells. SRF, serum response factor; ROCK, RhoA kinase; STARs, striated muscle activator of Rho signaling; MRTFs, myocardin families of transcription factors; DDR2, discoidin domain receptor 2; PDGF, platelet‐derived growth factor; ERK, extracellular signal‐regulated protein kinase; MAPK, mitogen‐activated protein kinase; TCFs, ternary complex factors; FOXO3, forkhead box O3; KLF4, Kruppel‐like transcription factor 4; MDM 4, Mouse Double Minute 4 protein; cIAP2, cellular inhibitor of apoptosis protein 2; Skp2, S‐phase kinase‐associated protein 2; PCNA, proliferating cell nuclear antigen.