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. Author manuscript; available in PMC: 2021 May 3.
Published in final edited form as: Gene Ther. 2020 Sep 3;28(3-4):142–154. doi: 10.1038/s41434-020-00190-1

Figure 2.

Figure 2.

Neurological exam performance of post-symptomatic AAV-treated SD cats versus untreated SD cats. Cats were given a neurological examination twice monthly and deficits were recorded. * Onset of deficit was significantly delayed compared to untreated SD cats (P ≤ 0.011); ▼, onset of deficit was significantly earlier compared to the EPS cohort (P ≤ 0.026). In the LPS cohort, pelvic hopping deficits and pelvic wheelbarrowing deficits were already apparent at the time of treatment for cat 7-866 and all deficits except thoracic wheelbarrowing were apparent at the time of treatment for cat 7-801. The first deficit to appear in untreated SD cats is pelvic hopping at 2.2 ± 0.7 months, and the last deficit to appear is thoracic wheelbarrowing at 3.0 ± 0.7 months. Abbreviations: P = pelvic limb; T = thoracic limb; EPT = extensor postural thrust; LPS = late post-symptomatic; EPS = early post-symptomatic. Data is expressed as mean ± s.d. No deficits were recorded in normal control cats.