Figure 3.

MRI evaluation of late post-symptomatic AAV-treated SD cats and untreated controls. T2-weighted MR images (3 Tesla) were taken at the level of the caudate nucleus (a, c and e) and DCN (b, d and f). Cortical white matter is hypointense to (darker than) gray matter in normal cats but hyperintense to (lighter than) gray matter in untreated SD cats. Also, the DCN area is hypointense to surrounding gray matter in normal cats (outlined black arrowhead in panel b) but becomes hyperintense with disease progression in untreated SD cats. In LPS cat 11-994 at humane endpoint, hypointensity of cortical white to gray matter is improved compared to untreated but is not normal. However, the DCN area has turned hyperintense to gray matter, similar to untreated SD cats. At the time of imaging cat 11-994 was on a clinical rating score of 3 (Figure 1a). There were no appreciable differences between a normal cat brain at 6 months old and at older ages. Brain atrophy, indicated by the amount of CSF (bright white area), in cat 11-994 was comparable to the untreated SD cat.