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. 2021 Mar 3;10:8. doi: 10.1186/s13619-020-00071-3

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© The Author(s) 2021, corrected publication 2024

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — RhoA loss- or gain-of-function affects the bone mass. Tibias from 8-week-old male mice with the genotypes of Col1-Cre (C), Col1-Cre;dnRhoA^+/− (Cdn) or Col1-Cre;caRhoA^+/− (Cda) were harvested for the following analyses. a, b Representative μCT images and parameters including BV/TV, Tb.Th, Tb.N, and Tb.Sp for the proximal tibias. c, d Representative images of H&E staining and quantification of Ob.N/BS and Ob.S/BS for the proximal tibia sections. e, f Representative images of Trap staining and quantification of Oc.N/BS and Oc.S/BS for the proximal tibia sections. g, h qPCR analyses for Alp, Bsp, Runx2, Lef1, Cyclin D1 (C.D1), and Axin2 mRNA levels in femurs. i, j Dynamic bone histomorphometry and quantification for BFR/BS, MAR, and dLS/BS. Mean ± SEM, ^*p < 0.05, ^**p < 0.01, n = 8, Tukey-Kramer multiple comparisons test