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. 2021 Feb 17;12:634553. doi: 10.3389/fgene.2021.634553

FIGURE 4.

FIGURE 4

Colocalization analysis of vitiligo, transcript of CDk10, and cg05175606. (A) Stacked association plots of vitiligo with the transcript of CDK10 in eQTLGen and GTEx sun-exposed skin eQTL data, and cg05175606 in meQTL data. HyPrColoc detected rs77651727 is the top-associated variant in eQTL and meQTL data. The variant is also associated with vitiligo at a genome-wide significant level. (B) HyPrColoc identified rs77651727 as a candidate causal variant explaining the shared association signal between the transcript of CDK10 and cg05175606, i.e., rs77651727 explained 100% of the posterior probability of colocalization. (C) HyPrColoc sensitivity analysis shows the transcript of CDK10 in two eQTL analysis and cg05175606 form a very strong cluster of colocalized traits.