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In silico modeling of Ras signalling network. (A) Scheme depicting the species and the reactions constituting the mathematical model. The parameters affected by cmp4 are indicated by red arrows. (B) Example of the output obtained simulating growth factor unstimulated (left) and stimulated (right) conditions of a wild type system. The level of effector activity, that is the level of the complex Ras-GTP-eff, is evaluated as the steady-state value reached during the dynamic simulation.
