Table 3.
Pulmonary function in CLAD (n = 17) and non-CLAD (n = 9) patients.
| Group | Baseline | 1 month | 3 months | 6 months | 12 months |
|---|---|---|---|---|---|
| FEV1, % of predicted value | |||||
| CLAD, mean (SD) | 51.8 (16.4) | 54.2 (16.7) | 48.2 (18.2) | 46.9 (20.8) | 48.3 (21.2) |
| Non-CLAD, mean (SD) | 74.8 (21.5) | 76.1 (22.0) | 78.0 (22.0) | 80.3 (20.9) | 77.8 (14.8) |
| p, difference CLAD versus non-CLAD | 0.005 | 0.010 | 0.001 | 0.001 | 0.004 |
| CLAD, mean difference (SE) | 2.0 (2.0) | −3.5 (3.1) | −4.6 (3.7) | −7.0 (5.0) | |
| p, difference from baseline | 0.339 | 0.274 | 0.233 | 0.196 | |
| Non-CLAD, mean difference (SE) | 1.2 (2.2) | 3.1 (3.5) | 4.2 (3.6) | 7.6 (4.9) | |
| p, difference from baseline | 0.597 | 0.402 | 0.283 | 0.166 | |
| FVC, % of predicted value | |||||
| CLAD, mean (SD) | 74.4 (14.8) | 76.6 (17.4) | 74.5 (18.3) | 68.0 (22.3) | 71.2 (16.5) |
| Non-CLAD (SD) | 81.8 (14.1) | 85.4 (15.7) | 83.6 (14.4) | 87.5 (16.8) | 84.1 (11.2) |
| p, difference CLAD versus non-CLAD | 0.231 | 0.225 | 0.207 | 0.036 | 0.078 |
| CLAD, mean difference from baseline (SE) | 3.5 (2.1) | 0.05 (3.1) | −2.5 (4.1) | −4.6 (3.8) | |
| p, difference from baseline | 0.128 | 0.985 | 0.544 | 0.266 | |
| Non-CLAD, mean difference from baseline (SE) | 3.5 (1.9) | 1.7 (2.2) | 5.6 (3.2) | 5.8 (2.6) | |
| p, difference from baseline | 0.112 | 0.458 | 0.119 | 0.058 | |
CLAD, chronic lung allograft dysfunction; FEV1, forced expiratory volume in first second; FVC, forced vital capacity; SD, standard deviation; SE, standard error.