Table 2.
Pearson correlation coefficients (R), percentage of genes changed by the pain state relative to naïve (%Cp), percentage of genes recovered by SCS (%RSCS) and percentage of genes that ended near naïve levels upon SCS treatment (%Dn) for each cell-specific transcriptome.
| Genes | %Cpa. | R | %R SCSb. |
%D nc. |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| DTMP | HRP | LRP | DTMP | HRP | LRP | DTMP | HRP | LRP | |||
| Resting | 1569 | 38% (↑49% ↓51%) | 0.65* | 0.42* | 0.39* | 83% | 70% | 59% | 68% | 50% | 46% |
| Post-injury | 3706 | 33% (↑61% ↓39%) | 0.65* | 0.47* | 0.17* | 84% | 75% | 53% | 61% | 52% | 41% |
| Inflammatory (CAIA) | 119 | 24% | 83% | 79% | 72% | 66% | 66% | 55% | |||
| Inflammatory (LPS) | 2100 | 36% | 84% | 76% | 48% | 57% | 49% | 36% | |||
| Ischemia | 1955 | 31% | 85% | 72% | 56% | 65% | 53% | 44% | |||
| Neuroprotective/repopulating | 1588 | 58% (↑47% ↓53%) | 0.58* | 0.48* | 0.17* | 76% | 70% | 56% | 53% | 44% | 38% |
| Neurodegeneration | 90 | 66% | 85% | 88% | 19% | 39% | 42% | 8% | |||
| TBI | 1491 | 57% | 75% | 68% | 58% | 53% | 44% | 39% | |||
| Systematic review | 20 | 45% | 89% | 89% | 78% | 67% | 44% | 44% | |||
a% of genes with expression level changes of at least 10% by the pain model relative to naive (%C ≥ 10%); ↑ = increased, ↓ = decreased.
b% of genes that returned toward naive levels upon treatment (Rf ≤ 1).
c% of genes that returned to within 15% of the expression level in naïve animals upon treatment (%CSCS ≤ 15%).
*Denotes significant (p < 0.05) correlations between naïve and each treatment.