TABLE 2.
Incidence of respiratory cancer including lung and laryngeal cancer according to the GGT points based on four consecutive examinations
| GGT points | Male | Female | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N | Events | IR a |
Model 1 aHR b (95% CI) |
Model 2 aHR (95% CI) |
N | Events | IR |
Model 1 aHR (95% CI) |
Model 2 aHR (95% CI) |
|
| Respiratory cancer | ||||||||||
| 0 | 1,595,879 | 4,855 | 0.47 | 1 (ref.) | 1 (ref.) | 566,518 | 713 | 0.20 | 1 (ref.) | 1 (ref.) |
| 1 | 260,084 | 989 | 0.59 | 1.25 (1.17, 1.34) | 1.15 (1.07, 1.23) | 153,299 | 250 | 0.26 | 1.30 (1.13, 1.50) | 1.00 (0.87,1.16) |
| 2 | 177,029 | 725 | 0.66 | 1.35 (1.25, 1.46) | 1.27 (1.17, 1.37) | 83,247 | 132 | 0.25 | 1.27 (1.06, 1.53) | 0.88 (0.73,1.06) |
| 3 | 181,702 | 767 | 0.66 | 1.39 (1.29, 1.50) | 1.30 (1.20, 1.40) | 70,183 | 151 | 0.35 | 1.73 (1.45,2.07) | 1.11 (0.93,1.33) |
| 4 | 355,079 | 1,608 | 0.71 | 1.51 (1.43, 1.60) | 1.39 (1.31, 1.48) | 116,089 | 238 | 0.33 | 1.67 (1.44, 1.93) | 0.96 (0.83,1.13) |
| p for trend | < 0.0001 | < 0.0001 | <.0001 | 0.86 | ||||||
| Laryngeal cancer | ||||||||||
| 0 | 1,595,879 | 293 | 0.03 | 1 (ref.) | 1 (ref.) | 566,518 | 3 | 0.0008 | 1 (ref.) | 1 (ref.) |
| 1 | 260,084 | 73 | 0.04 | 1.53 (1.18, 1.98) | 1.33 (1.02, 1.72) | 153,299 | 3 | 0.003 | 3.71 (0.75, 18.38) | 2.86 (0.57, 14.34) |
| 2 | 177,029 | 61 | 0.05 | 1.88 (1.43, 2.48) | 1.62 (1.22, 2.15) | 83,247 | 1 | 0.002 | 2.29 (0.24, 22.04) | 1.55 (0.16, 15.23) |
| 3 | 181,702 | 65 | 0.06 | 1.95 (1.49, 2.56) | 1.63 (1.24, 2.15) | 70,183 | 2 | 0.005 | 5.48 (0.92, 32.80) | 3.53 (0.57, 21.94) |
| 4 | 355,079 | 150 | 0.07 | 2.33 (1.91, 2.83) | 1.87 (1.51, 2.32) | 116,089 | 6 | 0.008 | 10.1 (2.52, 40.35) | 5.97 (1.38, 25.91) |
| p for trend | 642 | <.0001 | <.0001 | 0.0008 | 0.02 | |||||
| Lung cancer | ||||||||||
| 0 | 1,595,879 | 4,587 | 0.44 | 1 (ref.) | 1 (ref.) | 566,518 | 710 | 0.20 | 1 (ref.) | 1 (ref.) |
| 1 | 260,084 | 922 | 0.55 | 1.23 (1.15,1.33) | 1.14 (1.06, 1.22) | 153,299 | 247 | 0.26 | 1.29 (1.12, 1.49) | 0.99 (0.86, 1.16) |
| 2 | 177,029 | 666 | 0.58 | 1.31 (1.21,1.42) | 1.24 (1.14, 1.34) | 83,247 | 131 | 0.25 | 1.27 (1.05, 1.53) | 0.88 (0.73, 1.06) |
| 3 | 181,702 | 707 | 0.60 | 1.36 (1.26, 1.47) | 1.28 (1.18, 1.38) | 70,183 | 149 | 0.34 | 1.72 (1.44, 2.05) | 1.10 (0.92, 1.32) |
| 4 | 355,079 | 1,466 | 0.65 | 1.46 (1.37, 1.54) | 1.36 (1.27, 1.45) | 116,089 | 233 | 0.32 | 1.64 (1.41, 1.90) | 0.95 (0.81, 1.11) |
| p for trend | <.0001 | <.0001 | <.0001 | 0.72 | ||||||
Model 1 without any adjustments.
Model 2 adjusted for age, smoking status, alcohol habit, income, hypertension, dyslipidemia, diabetes, body mass index, and regular physical activity.
a
IR: incidence rates per 1000 person years.
b
aHR: adjusted hazard ratio.