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Chemical structures of 8-oxodG and its altered base-pairs. (A) ROS oxidize 2′-deoxyguanosine and generate 8-oxo-7,8-dihydro-deoxyguanosine (8-oxodG). (B) 8-oxodG in the syn conformation forms Hoogsteen base pair with 2′-deoxyadenosine, whereas 8-oxodG in the anti conformation forms Watson-Crick base pair with 2′-deoxycytidine.
