Fig. 7.

Nobiletin effectively suppresses the translocation of AIF under CI inhibition. The changes of expression levels of AIFs in nucleus (A, nAIF) and cytosol (B, cAIF). The treatment with rotenone (0.5 µM, 6 hours) significantly increased the expression of both nAIF and cAIF (ROT+). The pretreatment with nobiletin (30 µM, 1 hour) significantly blocked the effect of rotenone, reducing the expression levels of AIFs (ROT+ and NOB+). Data indicate the mean±S.E. **p<0.01, compared with non-treated group; ††p<0.05, compared with rotenone alone.