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Nobiletin dose-dependently increases the expression of antioxidant enzymes. (A) The changes of expression levels of Nrf-2 and HO-1 measured in HT-22 cells by a Western blot analysis. (B) The averaged expression level of Nrf-2. (C) The averaged expression level of HO-1. Both Nrf-2 and HO-1 were significantly increased by nobiletin (6 hours treatment) in a dose-dependent manner under a normal condition. Data indicate the mean±S.E. **p<0.01, compared with ‘0 μM NOB’.
