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. 2020 Nov 13;12(3):334–345. doi: 10.1111/jdi.13396

Figure 1.

Figure 1

Micro‐ribonucleic acid (miR)‐23a‐3p is downregulated, but NIMA‐related kinase 7 (NEK7) is upregulated in patients and rats with type 2 diabetes mellitus (T2DM). (a) miR‐23a‐3p and (b) NEK7 expressions detected in blood samples from patients with type 2 diabetes mellitus and healthy people (30 participants each) detected using reverse transcription quantitative polymerase chain reaction (RT–qPCR). (c) Oral glucose tolerance test and (d) insulin tolerance test results of patients with high or low expression of miR‐23a‐3p. (e) Pearson’s correlation analysis of correlation between miR‐23a‐3p and NEK7. The expression levels of (f) miR‐23a‐3p and (g) NEK7 in serum of type 2 diabetes mellitus and control rats detected by RT–qPCR (n = 8). (h) miR‐23a‐3p expression in the liver and kidneys of type 2 diabetes mellitus rats and control rats detected by RT–qPCR (n = 8). (i) NEK7 in the liver and kidneys from type 2 diabetes mellitus rats and control rats detected by western blot analysis. *P < 0.05. Measurement data were expressed by the mean ± standard deviation. Comparison between two groups was carried out by an unpaired t‐test. The correlation between NEK7 and miR‐23a‐3p was analyzed using Pearson’s correlation coefficient.