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Stoichiometry dictates whether a circular RNA can function as a microRNA sponge
(Left) A circular RNA that is expressed at low levels and has a single microRNA recognition element (MRE) is unlikely to out‐compete other cellular transcripts for binding to that microRNA. (Right) Only when a circular RNA is highly expressed and has many MREs, does it have the potential to titrate away the microRNA and serve as a sponge.
