Figure 5. Working model: MYC suppression of gene expression via m⁶A is critical for cancer progression.

MYC down‐regulates the m⁶A modification preferentially in certain MRGs, by up‐regulating the demethylase ALKBH5. The m⁶A reader YTHDF3‐mediated translation of MRGs SPI1 and PHF12 is attenuated as decreased m⁶A modification, and thus releases the inhibitory effect of MRGs on cell proliferation, thereby promoting cancer progression. The up‐direction red arrows indicate high, and down‐direction red arrows indicate low.