Figure 4.

Common proteins identified in the three replicates of canine in vitro oviductal cell-derived extracellular vesicles that participate in the canonical pathway (CP) ERK/MAPK signaling. The Ingenuity Knowledge Base defines this CP. The grey molecules highlighted with pink were identified in three biological samples of canine in vitro oviductal cell-derived extracellular vesicles. The arrows represent the directionality of the interaction between molecules or a molecule and a bio-function. The vertical tip represents inhibition. The solid line is for direct interaction, and the dashed line is for indirect interaction.