Table 2.
The top ten canonical pathways identified using the list of 398 common proteins from three biological samples of canine in vitro oviductal cell-derived extracellular vesicles.
| Canonical Pathway Defined by Ingenuity Knowledge Base | p-Value | # Ratio |
|---|---|---|
| EIF2 Signaling | 5.01 × 10−51 | 0.25 |
| Regulation of eIF4 and p70S6K Signaling | 3.98 × 10−27 | 0.20 |
| mTOR Signaling | 1.26 × 10−18 | 0.13 |
| Coronavirus Pathogenesis Pathway | 7.94 × 10−16 | 0.15 |
| Remodeling of Epithelial Adherens Junctions | 3.16 × 10−15 | 0.24 |
| Actin Cytoskeleton Signaling | 3.16 × 10−14 | 0.11 |
| Epithelial Adherens Junction Signaling | 1.58 × 10−13 | 0.13 |
| Integrin Signaling | 1.00 × 10−11 | 0.10 |
| Protein Ubiquitination Pathway | 2.51 × 10−11 | 0.08 |
| Glycolysis I | 7.94 × 10−11 | 0.35 |
Ratio: # of common proteins from three biological samples of canine in vitro oviductal cell-derived extracellular vesicles/# of molecules that define the canonical pathway based on the Ingenuity Knowledge Base.