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. 2021 Feb 22;9(2):449. doi: 10.3390/microorganisms9020449

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© 2021 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(a) Depiction of capsule switching between a genetic lineage 1* strain with a vaccine-type capsule (colored green) and a genetic lineage 2* strain with a non-vaccine type capsule (colored red). Diagram based on information from Swartley et al. [48]. (b) Illustration of capsule replacement when the vaccine capsule type (colored green) strain of genetic lineage 1* is removed by the vaccine, leaving the strain of genetic lineage 2* with non-vaccine capsule (colored red) to remain and proliferate. Diagram based on information from Lipstich M [49]. (c) Another scenario of capsule replacement when strain of genetic lineage 1* with both vaccine (colored green) and non-vaccine (colored red) capsule types are present before vaccine introduction and after vaccine use, only the non-vaccine capsule type of genetic lineage 1* strain remains. Diagram based on information from Lipstich M [49].