. 2021 Feb 22;9(2):449. doi: 10.3390/microorganisms9020449

Table 2.

Licensed vaccines * against Haemophilus influenzae, Neisseria meningitidis and Streptococcus pneumoniae.

Origanism	Vaccine Type	Serotype/Serogroup Targets	Protein Carrier ^†	Year First Licensed
H. influenzae	Hib conjugate	b	TT, OMP	1987
N. meningitidis	tetravalent polysaccharide	A, C, Y and W	None	1974
N. meningitidis	monovalent C conjugate	C	CRM₁₉₇, TT	1999
N. meningitidis	monovalent A conjugate	A	TT	2010
N. meningitidis	tetravalent conjugate	A, C, Y and W	CRM₁₉₇, DT, TT	2005
N. meningitidis	4 component MenB	B	protein base vaccine	2013
N. meningitidis	factor H binding protein	B	protein base vaccine	2018
S. pneumoniae	PCV7 conjugate	4, 6B, 9V, 14, 18C, 19F, 23F	CRM₁₉₇	2000
S. pneumoniae	PCV10 conjugate	1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F, 23F	CRM₁₉₇, TT, DT	2009
S. pneumoniae	PCV13 conjugate	1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, 23F	CRM₁₉₇	2011
S. pneumoniae	PPV23 plain polysaccharide	1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F, 33F	None	1983

* Except for the 4 component MenB and the factor H binding protein vaccines, all the other vaccines described in this Table are polysaccharide based vaccines. ^† protein carriers include TT (tetanus toxoid), DT (diphtheria toxoid), CRM₁₉₇ (mutant diphtheria toxoid), OMP (outer membrane protein of N. meningitides).