Changes in mean concentrations of leptin, adiponectin, hepatocyte growth factor (HGF), insulin, and lipase in human milk after the HPP + Lyo processes and 3-month storage compared with raw human milk. The data are presented as mean values with the standard error of the mean. The percentage of concentrations of the selected bioactive components in milk samples subjected to HPP + Lyo at time 0 (0) and at 3 months (3) compared to raw human milk (100%) (3). Statistically significant differences were observed and marked with asterisks, depending on the degree of significance (*** p < 0.0001, ** p < 0.001), only adiponectin (at time 0, p = 0.0002; at month 3, p < 0.0001) and HGF (at month 3, p = 0.0049). The differences in leptin, insulin, and lipase levels measured in treated (HPP + Lyo) milk samples stored for 3 months and in raw milk samples were not statistically significant (p > 0.05).