Figure 4.

KRAB-ZFPs oncogene and tumor suppressor genes (TSG) role in the cancers of various tissue origins. The scheme presents the localization of different cancers in the human body, in which KRAB-ZFP factors may act as oncogenes (red font, the gene is upregulated) or tumor suppressor genes (green font, the gene is downregulated). Abbreviations: BLCA—bladder cancer, BRCA—breast cancer, CAA—cholangiocarcinoma, CESC—cervical cancer, CLL—chronic lymphocytic leukemia, CRC—colorectal cancer, EC—endometrial cancer, ESCC—esophageal squamous-cell carcinoma, GBM—glioblastoma, HCC—hepatocellular carcinoma, LUC—lung cancer, MM—multiple myeloma, OD—oligodendroglioma; OvCa—ovarian cancer, PAAD—pancreatic cancer, PRAD—prostate adenocarcinoma, RCC—kidney cancer, SC—skin cancer, SKCM—melanoma, STAD—gastric cancer, THCA—thyroid cancer.