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A summary of the GSK3α/β signaling pathways in macrophage functions and related diseases. In macrophages GSK3α/β can be activated or inactivated by different upstream signaling pathways. GSK3α/β has a large number of downstream substrates that regulate a variety of different downstream signaling pathways to control macrophage phenotype and function. Dysregulation of one or more of these pathways has been implicated in the development of several different disorders/diseases.
