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. 2021 Feb 22;22(4):2165. doi: 10.3390/ijms22042165

Table 1.

A summary of exosomes related to different female reproductive system diseases.

Disease Source Studied cargo Type Clinil Level Clinical Value References
PCOS Follicular fluid miR-25-3p, miR-143-3p, miR-193b-3p, miR-199a-5p, miR-199a-3p, miR-199b-3p, miR-629-5p, miR-4532, miR-4745-3p, miR-6087 miRNA Up Diagnosis and Target therapy [66]
Follicular fluid miR-10a-5p, miR-23b-3p, miR-98-5p, miR-141-3p, miR-200a-3p, miR-200c-3p, miR-382-5p, miR-483-5p, miR-483-3p, miR-3911 miRNA Down Diagnosis and Target therapy [66]
Follicular fluid miR-146a-5p, miR-126–3p miRNA Up Diagnosis and Target therapy [68]
Follicular fluid miR-20b-5p, miR-106a-5p, miR-18a-3p miRNA Down Diagnosis and Target therapy [68]
AMSCs miR-323-3p miRNA - Stem cell therapy [69]
Serum miR-27a-5p miRNA Up Target therapy [70]
Follicular fluid hsa_circ_0006877 circRNA Down Target therapy [72]
Urine DENND1A.V2 Protein Up Target therapy [74]
Follicular fluid S100-A9 Protein Up Target therapy [77]
POF BMSCs miR-664-5p miRNA - Stem cell therapy [87]
BMSCs miR-144-5p miRNA - Stem cell therapy [88]
hAECs miR-1246 miRNA - Stem cell therapy [89]
AFSCs miR-10a, miR-146a miRNA - Stem cell therapy [90]
PD-MSCs antioxidant enzymes [e.g., catalase, and PRDX1] Protein - Stem cell therapy [91]
Asherman syndrome MSCs MMP-2, MMP-9, PCNA, CD31, VEGFR1 Protein Up Stem cell therapy [94]
MSCs TIMP-2 Protein Down Stem cell therapy [94]
Endometriosis Serum miR-320a miRNA Up Diagnosis [101]
Peritoneal macrophages miR-22-3p miRNA Up Diagnosis and Target therapy [120]
ECC1 cells miR-17, miR-106a, miR-200c miRNA Up Diagnosis and Target therapy [22]
Endometrial fluid miR-30d miRNA Target therapy [109]
Endometrial stromal cells hsa-miR-494- 3p, hsa-miR-10b-3p, hsa-125b-2-3p, hsa-miR-1343-3p miRNA Up Target therapy [110]
Macrophages miR-223 miRNA Target therapy [114]
Stroma-ectopic cells miR-214 miRNA Down Target therapy [116,117]
Ectopic endometriotic lesions LINC00998, NEAT1, PVT1, H19, RP4-561L24.3 LncRNA Up Target therapy [112]
Ectopic endometriotic lesions LINC00293, LINC00929, MEG8, SNHG25, RP5-898J17.1 LncRNA Down Target therapy [112]
Ectopic endometria, serum, ECSCs aHIF LncRNA Up Diagnosis and Target therapy [123]
Peritoneal fluid PRDX1, ITIH4, ANXA2, tubulin α-chain Protein Up Diagnosis [111]
Endometrial Cancer CAFs miR-148b miRNA Down Target therapy [130]
CAFs miR-320a miRNA Down Target therapy [131]
Endometrial cancer cells miRNA-21 miRNA Up Target therapy [133]
Peritoneal lavage miR-10b-5p, miR-34b-3p, miR-34c-5p, miR-34c-3p, miR-449b-5p, miR-200b-3p, miR-383-5p, miR-2110 miRNA Down Diagnosis [134]
Urine hsa-miR-200c-3p miRNA Up Diagnosis [135]
Supernatants of endometrial cancer cell lines miR-133a miRNA Up Target therapy [136]
Serum hsa circ 0109046, hsa circ 0002577 circRNA Up Diagnosis [137]
Plasma LGALS3BP Protein Up Target therapy [132]
Peripheral and uterine blood TF+, CD144+, CD14+ Protein Up Diagnosis [138]
Cervical Cancer Cervicovaginal lavage miR-21, miR-146a miRNA Up Diagnosis [144]
Plasma let-7d-3p miR-30d-5p miRNA Up Diagnosis [145]
Plasma miR-125a-5p miRNA Down Diagnosis [146]
Cervical cancer cell lines miR-221, miR-222 in miRNA Up Diagnosis and Target therapy [147,148,149,150]
HEK293 miR-22 miRNA Down Target therapy [151]
HeLa HNF1A-AS1 LncRNA Up Diagnosis [152]
Cervicovaginal lavage HOTAIR, MALAT1, MEG3 LncRNA Up Diagnosis [153]
Serum EXOC7 LncRNA Up Diagnosis [154]
CerEpiC, HeLa, CaSki TUG1 LncRNA Up Diagnosis [155]
Cervical cancer cell lines Patched1, Smoothened, Sonic hedgehog, Indian hedgehog Protein Up Target therapy [156]
Mouse cervical cancer cells ATF1, RAS Protein Up Target therapy [157]
Ovarian Cancer Serum miR-21 miRNA Up Diagnosis and Target therapy [189]
Plasma miR-100, miR-320 miRNA Up Diagnosis [182]
Plasma miR-16, miR-93, miR-126 miRNA Down Diagnosis [182]
Paclitaxel-resistant ovarian cancer cell miR-106a miRNA Up Drug resistance [175]
Paclitaxel- and cisplatin-resistant ovarian cancer cell miR-130a miRNA Down Drug resistance [176]
Serum miR-200 miRNA Up Diagnosis [179,180,181]
Ovarian cancer tissues miR-221, miR-222 miRNA Up Drug resistance and Target therapy [174]
Macrophages miR-223 miRNA Up Drug resistance [178]
Paclitaxel-resistant ovarian cancer cell miR-591 miRNA Down Drug resistance [175]
Ovarian cancer cell lines miR-433 miRNA Down Drug resistance [173]
Ovarian cancer cell lines CD9, CD63 Protein Up Diagnosis and Target therapy [168]
Ovarian cancer cell lines CD24 Protein Up Diagnosis and Target therapy [165]
Epithelial ovarian cancer CD44 Protein Up Diagnosis and Target therapy [166]
Serum Hsp27 Protein Up Diagnosis and Target therapy [169]
Dendritic cells MHC I, Hsp70, Hsp90 Protein Up Diagnosis and Target therapy [167]
Ovarian cancer cell lines Aldehyde reductase, phosphate isomerase, fatty acid synthase, and peroxiredoxin Protein Up Diagnosis and Target therapy [162,170]
Ovarian cancer cell lines LPL, COL5A2 Protein Up Diagnosis and Target therapy [171]
Cisplatin-resistant ovarian cancer cells Annexin A3 Protein Up Drug resistance [172]
Preeclampsia Extravillous trophoblast cells miR-23a-3p, miR-125b-2-3p, miR-144-3p, miR-192-5p, miR-205-5p, miR-208a-3p, miR-335-5p, miR-451a, miR-518a-3p, miR-542-3p miRNA Down Diagnosis [217]
Extravillous trophoblast cells let-7a-5p, miR-17-5p, miR-26a-5p, miR-30c-5p, miR-141-3p, miR-199a-3p, miR-221-3p, miR-584-5p, miR-744-5p, miR-6724-5p, * hsa-miR-525-5p, * hsa-miR-526b-5p, * hsa-miR-1269b miRNA Up Diagnosis and Target therapy [217]
Placental trophoblast Syncytin-2 Protein Down Target therapy [205]
Syncytiotrophoblast Tissue factor Protein Up Target therapy [209,210]

* These three miRNAs were recognized only in the disease conditions. miR, miRNA, microRNA; PCOS, polycystic ovary syndrome; POF, premature ovarian failure; AMSCs, adipose mesenchymal stem cells; BMSCs, bone mesenchymal stem cells; hAECs, human amniotic epithelial cells; AFSCs, PD-MSCs, amniotic fluid stem cells; placenta-derived mesenchymal stem cells; peroxiredoxin; MMP-2, matrix metalloproteinase-2; PCNA, proliferating cell nuclear antigen; CD31, cluster of differentiation 31; VEGFR1, vascular endothelial growth factor receptor-1; TIMP-2, tissue inhibitor of metalloproteinase-2; aHIF, antisense hypoxia-inducible factor; ITIH4, inter-α-trypsin inhibitor heavy chain H4; ANXA2, annexin A2; CAFs, cancer-associated fibroblasts; LGALS3BP, lectin galactoside-binding soluble 3 binding protein; ATF1, activating transcription factor 1; Hsp27, heat shock protein 27; LPL, lipoprotein lipase; COL5A2, collagen type V alpha 2 chain.