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. 2021 Feb 22;22(4):2185. doi: 10.3390/ijms22042185

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Increasing concentrations of cryoprecipitate, but not fibrinogen concentrate, enhances the thrombin generation potential. Increasing concentrations of fibrinogen from either fibrinogen concentrate (Fg-C—blue) or cryoprecipitate (cryo—red) were added to fibrinogen deficient plasma (FDP) and thrombin generation tests performed. (A) Lag time (B) time to peak, (C) peak height and (D) endogenous thrombin potential (ETP) are shown. Levels of statistical significance are depicted on each relevant graph. Normal ranges are shown by grey dotted lines. Data are represented as mean ± SD. * p < 0.05, **** p < 0.0001. n = 2, assays performed in triplicate.