Table 1.
Constituents of fibrinogen sources.
| PNP | FDP | Cryoprecipitate | Fg-C | |
|---|---|---|---|---|
| Clauss Fg (g/L) | 3.3 ± 0.3 | <0.15 | 6.8 ± 0.1 | 21.6 ± 0.1 |
| FII (%) | 98 ± 4 | 98 ± 7 | 101 ± 12 | <1 |
| FV (%) | 82 | 36 ± 0.7 | 68 ± 9 | <1 |
| FVII (%) | 84 ± 1 | 75 ± 4 | 81 ± 7 | <1 |
| FVIII (%) | 107 ± 14 | 43 ± 5 | 190 ± 0.6 | <1 |
| FIX (%) | 127 ± 25 | 106 ± 3 | 105 ± 8 | 2 |
| FX (%) | 92 ± 7 | 95 ± 3 | 98 ± 14 | <1 |
| FXI (%) | 100 ± 16 | 107 ± 4 | 92 ± 3 | <1 |
| FXIII (%) | 80 ± 7 | <5 | 105 ± 3 | <1 |
| vWF:Ag (%) | 127 ± 33 | 65 ± 1 | 288 ± 66 | 66 |
| α2AP (µg/mL) | 72 ± 20 | 38 ± 3 | 98 ± 8 | 1 ± 3 |
Clauss fibrinogen and coagulation factors II, V, VII, VIII, IX, X, XI, XIII and vWF antigen were quantified using a Sysmex CS-5100 haematology analyser in pooled normal plasma (PNP), fibrinogen-deficient plasma (FDP), cryoprecipitate and fibrinogen concentrate (Fg-C). Results are represented by the mean ± SD and expressed as a percentage (%) of normal, except for Clauss fibrinogen which is reported as a concentration (g/L). The normal range for all factor assays is 50–150% and Clauss fibrinogen 1.5–4.5 g/L. n = 2. α2AP levels were quantified using an in-house enzyme-linked immunosorbent assay (ELISA). n = 7.