Table 1.
Host cell receptors/co-receptors for entry of viruses in the Bunyavirales order.
| Genus/Family | Receptor/Co-Receptors | Virus Name | References |
|---|---|---|---|
|
Mammarenavirus Arenaviridae |
α-DG | LASV, LCMV, OLVV, MOBV, LATV | [92,93] |
| LAMP1 | LASV | [94,95] | |
| TfR1 (CD71) | MACV, JUNV, WWAV, GTOV, SBAV, CHPV, TAMV | [96,97,98,99] | |
| DC-SIGN, LSECtin | LASV, LCMV | [100,101] | |
| Axl, Tyro3 | LASV, LCMV | [100,101] [102] | |
| NRP2 | LUJV | [103] | |
| Tetraspanin (CD63) | |||
| (VGCCs) | JUNV | [104] | |
|
Orthobunyavirus Peribunyaviridae |
HSPG | AKAV, SBV | [105] |
| DC-SIGN | GERV, LACV | [106,107] | |
|
Orthohantavirus Hantaviridae |
αvβ3 integrins | SNV, NYV, HTNV, SEOV, PUUV, ANDV | [108,109,110] |
| PCDH1 | ANDV, SNV, PHV, MAPV | [111] | |
| β2 integrin | HTNV | [112] | |
| α5β1 integrin | PHV | [108] | |
| DAF (CD55) | HTNV, SNV | [113,114] | |
| gC1qR | HTNV | [115] | |
| 70-kDa protein | HTNV | [116] | |
|
Orthonairovirus Nairoviridae |
DC-SIGN | CCHFV | [117] |
| Nucleolin | [118] | ||
|
Phlebovirus Phenuiviridae |
DC-SIGN | RVFV, TOSV, PTV | [106,119,120] |
| L-SIGN (CD209L) | RVFV, TOSV | [119] | |
| HSPG | RVFV, TOSV, | [121,122,123] | |
| PNASEK | RVFV | [124] | |
|
Uukuvirus Phenuiviridae |
DC-SIGN L-SIGN (CD209L) |
UUKV | [106,119] |
|
Bandavirus Phenuiviridae |
DC-SIGN, DC-SIGNR, LSECtin | SFTSV | [107,120] |
| NMMHC-IIA | [125,126] | ||
|
Tenuivirus Phenuiviridae |
LsTUB | RSV | [127] |
|
Orthotospovirus Tospoviridae |
50 kDa thrips protein | TSWV | [128,129] |
| 94 kDa thrips protein | [130] | ||
| TSWV Gn-interacting thrips proteins | [131] |
AKAV, Akabane virus; α-DG, alpha-dystroglycan; ANDV, Andes virus; Axl, Axl receptor tyrosine kinase; CCHFV, Crimean-Congo hemorrhagic fever virus; CHPV, Chapare virus; DAF, Decay-accelerating factor; DC-SIGN, Dendritic cell-specific intracellular adhesion molecule-3-grabbing non integrin; DC-SIGNR, DC-SIGN-related; GERV, Germiston virus; GTOV, Guanarito virus; HSPG, Heparan sulfate proteoglycan; HTNV, Hantaan virus; JUNV, Junín virus; LACV, La Crosse virus; LAMP1, Lysosome-associated membrane protein 1; LASV, Lassa virus; LATV, Latino virus; LCMV, lymphocytic choriomeningitis virus; LSECtin, C-type lectin receptor; L-SIGN, liver-specific intercellular adhesion molecule-3-grabbing non-integrin; LsTUB; L. striatellus α- tubulin 2; LUJV, Lujo virus; MACV, Machupo virus; MAPV, Maporal virus; MOBV, Mobala virus; NRP2, Neuropilin-2; NYV, New York virus; NMMHC-IIA, Non-muscle myosin heavy chain IIA; OLVV, Oliveros virus; PCDH1, Protocadherin-1; PHV, Prospect Hill virus, PNASEK, Proteinase K; PTV, Punta Toro virus; PUUV, Puumala virus; RSV, rice stripe virus; RVFV, Rift Valley fever virus; SBAV, Sabiá virus; SBV, Schmallenberg virus; SEOV, Seoul virus; SFTSV, severe fever with thrombocytopenia syndrome virus; SNV, Sin Nombre virus; TAMV, Tamiami virus; TfR1, Transferrin receptor protein 1; TOSV, Toscana virus; TSWV, Tomato spotted wilt virus; Tyro3, tyrosine-protein kinase receptor 3; UUK, Uukuniemi virus; VGCCs, Voltage-gated calcium channels; WWAV, Whitewater Arroyo virus.