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. 2021 Feb 21;9(2):220. doi: 10.3390/biomedicines9020220

Table 1.

Multiple sequence analysis of TMEM163 and ZnT protein family using Clustal Omega (MegAlign Pro, Lasergene v17.1). Percent identity and similarity are shown by the upper right values (bold text) and lower left values (regular text), respectively. The identity percentage signifies the number of amino acids that exactly matches sequences between two proteins, while similarity percentage represents the likelihood that the two proteins have evolved from a common ancestral protein. MegAlign Pro calculated the numerical values with the following parameters: distance metric = Uncorrected Pairwise; Gap treatment = Pairwise gap removal; Residues considered = 163–460.

TMEM163 ZnT1 ZnT2 ZnT3 ZnT4 ZnT5 ZnT6 ZnT7 ZnT8 ZnT9 ZnT10
TMEM163 0 17.6 10.3 11.5 11.2 9.5 11.7 14.7 10.8 24.2 18.9
ZnT1 36.5 0 30.5 27.1 25.8 25.6 16.1 26.5 27.3 14.5 38.9
ZnT2 35.3 50.8 0 53.7 38.4 22.6 18.4 22.5 50.6 14.9 24.8
ZnT3 28.6 45.4 67.5 0 35.1 20.5 20.2 22.3 44.5 13.4 22.7
ZnT4 29.4 49.4 60.8 57.4 0 22.6 18.5 22.4 39.2 15.4 25.2
ZnT5 32.1 48.8 45.0 42.5 44.2 0 24.3 43.6 21.6 16.0 25.9
ZnT6 29.4 34.3 38.1 37.1 39.7 47.0 0 24.6 18.2 14.5 16.7
ZnT7 36.8 48.8 46.4 42.6 47.8 63.0 44.5 0 21.8 15.4 27.8
ZnT8 30.8 52.3 69.1 64.3 61.0 44.1 37.9 42.9 0 14.9 25.7
ZnT9 46.1 36.6 36.1 31.4 34.0 34.4 30.1 35.2 33.4 0 17.3
ZnT10 36.0 54.1 47.6 44.5 48.8 43.7 38.0 45.8 50.0 37.3 0