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Schematic structure of the 5′ promoter (A) of the PFKFB4 gene (B). PFKFB4 contains 14 exons. Numbers in (A) represent: 1—GRE (glucocorticoid response element), 2—AP-2 (activating protein 2), 3—specific protein 1, 4—TATA box, 5—serum response element, 6—hypoxia response element, 7—ETF. The schematic structures are based on Gomez et al. (2004) [17].
