Figure 2.

Actin regulatory proteins controlling TGFβ type I receptors (TβRI) and II trafficking. (a) The internalized TβRI into clathrin-coated vesicles is linked to the actin cytoskeleton via fascin actin-bundling protein 1 (FSCN1) which promotes the trafficking of internalized receptors from clathrin-coated vesicles to early endosomes and thus TGFβ signaling. (b) VASP promotes TGFβ activity by sustaining the complex between Rab11 and TβRII that favors TβRII recycling to the plasma membrane. (c) Myosins sustain TGFβ signaling by sustaining the cell-surface expression of TβRII receptor and inhibiting its degradation. (d) Arf GAP with GTP-binding protein-like domain, Ankyrin repeat, and PH domain 2 isoform 2 (AGAP2) sustains TGFβ signaling, by directly or indirectly interacting with TβRII and sustaining the recycling of the receptor to the plasma membrane.