Figure 4.
Natural selection strength assessment. The strength of host selection on virus populations was compared between clinical categories. Left: dN/dS ratio over all coding positions. dN/dS ratio of 1, is interpreted as evidence for neutral evolution (dotted line). dN/dS > 1 represents positive selection, while dN/dS < 1 represents a negative (purifying) selection. Right: Number of accumulated iLVs. In all cases, each dot represents a sample and the lines are the median with the IQR. (*) p < 0.01; (****) p < 0.0001; Ns: not significant.