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. 2021 Feb 22;10(2):472. doi: 10.3390/cells10020472

Figure 8.

Figure 8

Prediction of fatty acid (FA)-binding pockets in Nups. (A) Table compiling the prediction information for all the Nups present on WT LD. Indicated are the presence (or absence, x) of an available PDB ID to be used for the prediction. Only positive results (where “False” is assigned to scores below 0.5, while “True” spans up to the perfect match of 1, see M&M) are indicated upon running PickPocket, which is either trained with an All Species Model or a Human-Only Model. The protein chain and the aminoacids stretch harboring the predicted pocket are also shown. (B) Structure of Nup157 (aminoacids 70-893; PDB 4HMC), in which the position and orientation of the predicted FA-binding pocket is highlighted as a filled space. An inset of the coordination of the FA with Tyr594 (magenta) and Tyr646 (orange) is shown. (C) Structure of Nic96 (amino acids 185-839; PDB 2QX5), in which the position and orientation of the predicted FA-binding pocket is highlighted as a filled space. The different domains of the protein have been named for clarity.