Table 4.

Direct and indirect angiogenesis inhibitors.

Direct	Indirect
Angiostatin, bevacizumab (Avastin) Arresten, canstatin, combrestatin Endostatin, thrombospondin Tumstatin, methoxyestradiol, vitaxin	Targeting EGF-receptor tyrosine kinase Sunitinib Targeting the VEGF receptor Targeting the PDGF receptor Targeting Erb-B2 Receptor Tyrosine Kinase 2 (ERBB-2) Targeting the interferon alpha receptor *

* Interferon alpha can be considered both a direct angiogenesis inhibitor because it inhibits endothelial migration and an indirect angiogenesis inhibitor because it inhibits synthesis of FGF by tumour cells [57,89].