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The molecular mechanisms of statins’ impact on PON1 gene expression in the example of pitavastatin. Pitavastatin increases phosphorylation of p44/42 mitogen activated protein (MAP) kinase and protein kinase C stimulates Sp1 and SREBP binding to the PON1 promoter and enhances the gene expression [147,148]. The inhibition of the farnesyl pyrophosphate formation results in enhanced binding of regulatory proteins to the PON1 promoter [149].
