Table 1.

The relationship of noncoding DNA of PON cluster gene variations and PON’s activity.

PON Activity	Polymorphic Site (Functional Alias)	DbSNP Rs Number	References
Responsible for 22.8% variation in arylesterase activity; C allele associated with higher PON1 activity towards paraoxon, phenyl acetate and PON1 concentration; the highest PON1 activity and concentration is seen in CC genotype, medium in CT and the lowest in low-expressor genotype (TT)	-107/108 C/T; PON1 promoter	rs705379	[31,43,54,57]
Influence on PON1 arylesterase activity	-162 A/G PON1 promoter	rs705381	[54]
Influence on PON1 arylesterase activity	-907/909 C/G PON1 promoter	rs854572	[54]
Influence on PON1 arylesterase and paraoxonase activity	PON1 introns	rs854567	[31]
		rs2299257
		rs3917486
	PON2 intron	rs2375005
PON1 activity towards paraoxon higher in the presence 17899insTT/insTT and 17974 CT or TT PON1 activity towards phenyl acetate higher for 1799delTT/del TT	17899insdelC/T PON1 intron 5 17974 C/T PON1 intron 5		[58]
Associated with PON3 concentration	-567 C/T PON3 promoter -665 A/G PON3 promoter -746 C/T PON3 promoter		[35]
Differences in PON1 efficiency in atorvastatin δ -lactone hydrolysis	-4984 G/A PON3 promoter -4105 G/A PON3 promoter -1091 A/G PON3 promoter -746 C/T PON3 promoter		[73]