Table 3.

The clinical relevance of noncoding DNA polymorphism of PON cluster in stroke.

Clinical Relevance	Polymorphic Site (Functional Alias)	DbSNP Rs Number	References
T allele increased the overall risk of arterial ischemic stroke in young adults (age <45); TT genotype two times increased risk of acute hemispheric stroke in the elderly (age >56)	-107/108 C/T; PON1 promoter	rs705379	[103,104]
A/G polymorphism associated with risk of total and ischemic stroke	-162 A/G PON1 promoter	rs705381	[106]
G/A variations were independent predictor of carotid IMT; A allele identified as protective factor	-824/-832 G/A PON1 promoter	rs854571	[105,106]
CT or TT genotype via miR 616 associated with lower risk of ischemic stroke and lesser extent of carotid atherosclerosis	3′UTR PON1	rs3735590	[60]