Table 5.

The clinical relevance of noncoding DNA polymorphism of PON cluster in peripheral artery disease, dementia and renal disease.

Clinical Relevance	Polymorphic Site (Functional Alias)	DbSNP Rs Number	References
Higher frequency of C allele in lupus erythematosus (LE) renal disease; allele C frequency higher in patients with non- progressive IgA nephropathy Allele T more frequent in patients with AD, TT genotype associated with unfavorable lipid profile in patients with AD of late onset; in meta – analysis allele A associated with higher risk of AD, protective role of GG genotype entry 1	-107/108 C/T; PON1 promoter	rs705379	[124,125,126,127,128,134]
Higher frequency of A allele in LE renal disease; Higher albumin loss in diabetic patients with allele A	-160/-162 A/G PON1 promoter	rs705381	[124,119]
Higher frequency of G allele in LE renal disease; Higher albumin loss in diabetic patients with allele G	-1074 A/G		[124,119]