Figure 3.
Effects of RU486 on progesterone-induced contractions in the resting myometrium and on progesterone-induced inhibitions against high-KCl-induced contractions. (A) Representative myograph of six myographs was obtained when the resting myometrial strips were pretreated with RU486 (10−7 M) or a vehicle for 60 min, progesterone was added at 5 × 10−6 or 5 × 10−5 M, and myometrial strips were cotreated with RU486 or a vehicle for 20 min. (B) Time-dependent changes in the relative ratio of the peak area (RRPA) of progesterone-induced contractions in the RU486- and vehicle-treated groups. (C) Representative myograph of six myographs obtained when myometrial strips contracted by high KCl were pretreated with RU486 or a vehicle for 60 min, progesterone was added at 5 × 10−6 M, and the strips were cotreated with RU486 or a vehicle for 20 min. (D) Time-dependent changes in the RRPA of high-KCl-induced contractions in the RU486- and vehicle-treated progesterone groups.