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Illustration of the homing endonuclease (HE, meganuclease) and CRISPR/Cas9 System: (a) Homing endonuclease-mediated recognition and binding of a DNA substrate leads to the cleavage of the substrate.; (b) A custom-designed guide RNA (gRNA) hybridizes its target sequence and directs Cas9 endonuclease to cleave a DNA substrate.
