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Reporter assay reconfirmation. NleB inhibition and luciferase inhibition assay results of eight primary targets from the Food and Drug Administration (FDA) and Bioactives libraries with IC50s < 5 μM. Luciferase assays were conducted as described for HTS assays. NleB activity inhibition is plotted in green and luciferase activity inhibition is plotted in red, both as a function of individual compound concentrations from 0–40 µM.
